Aging is a mortal disease. Let's treat it as such! — Yuri Deigin



A few days ago I was invited to post a video with my thoughts on why I think the Movement for Indefinite Life Extension is important,
and to answer a question whether I personally would accept an indefinite
lifespan, should one be available. Of course for me the answer is obvious:
yes, I would accept an indefinite lifespan just by virtue of it offering me more choice
than I have right now than my current fixed lifespan. I mean, if I don't like
it, I can always end it. But that flexibility is unavailable right now.
Right now we don't get to decide how long we get to live. We are actually
hostages of our biology, it's our genes that decide how long we get to live, as
they do for all their replicators. Starting from bacteria to mice, to men, to
whales, to whatever. So we're essentially like hostages
on death row who are guaranteed to die within 80 to 100 years,
pretty much. I mean, the odds of living past 100 years are 1 in a million
and statistically no one has ever lived past 122 years, so if nothing changes we are guaranteed to die. And not just that, we're guaranteed to suffer.
I mean, starting from a certain age the aging process just becomes
unbearable and it's painful, emotionally and physically and that really sucks! Aging sucks, death sucks, and if we don't
do anything about it, we're just going to succumb to it. I think that's a big problem
that we need to acknowledge. It's kind of odd for me to see that not
many people acknowledge that this is a problem: most people take it for granted
that, you know, aging is a part of life and death is a part of life… I mean, they are but they're a bad part of life, so we should do everything possible to
mitigate it or get rid of it. It's funny that most people only start doing something about trying to prolong their lifespan once
they find themselves terminally ill with some condition like cancer when they
know that they got only like a year left to live and so then they start doing
everything possible to prolong their life — to get cured of cancer. At that
point they really become life extensionists because they're trying pretty much
anything — they would try anything — to get rid of the condition that gives them
guaranteed death. But if people aren't sick, for them guaranteed death within
30 to 50 years is not a big deal for some reason. To me that is something that
we should try to change in society with trying to, first of all, educate
people that aging is plastic, that it's reversible — in animals at least —
I mean, we've seen this in cells with induced pluripotent stem
cells that are actually rejuvenated. Or in some animals like mice that are actually rejuvenated by
induction of pluripotency genes — but I'm going off on a tangent.
What I really want to say is that for the Movement for Indefinite Life Extension
to succeed I think we should instill a sense of urgency in others
that we actually are terminally ill. All of us are terminally ill with this
genetic condition of AGING, which brings us guaranteed death —
it's a mortal disease, and we should treat it as such! I mean, scientists — some scientists — that specialize in aging have been aware of this of these pathologies
that are at some point amenable to mitigation, to pharmacological
manipulation, and now we should translate all those findings, all that research
into humans and do it as fast as possible. Because right now — I mean, it's
great that scientists or researchers are doing all that research,
but they can be doing it for another decade or two before we get to see
meaningful translation to the human domain, and I don't think we have that luxury. We don't have that time. I mean, our generation — if the therapy becomes available in 30 years, we're also gonna
be pretty late but think about our parents, think about our grandparents!
Those generations — if we don't hurry up — they face very slim odds of living long
enough to to be able to extend their lives and this sucks too! I really don't want anybody to succumb to death and aging, and I really want all
generations to be able to benefit from these therapies. I think these
therapies can be — some meaningful life extension can be gained from translation
of already existing mechanisms of aging interventions. This is why we're
working on epigenetic rejuvenation right now. So I think if we do instill that
sense of urgency in people, we can start changing the society to actually wake up
to the problem of aging and this will create — I think — will create a groundswell of
public support for funding of primary research into aging mechanisms and will
actually pressure scientists into translating all their findings and doing it
as fast as possible. If we give the sense of urgency into the scientists that waiting for another decade or two is not acceptable for us, I think this
can really speed things up. I think a great example of the kind of activism that we should embrace is what has been demonstrated by HIV infected
people back in the 1980s where initially the diagnosis of HIV was
essentially a death sentence with people only getting 18 months left to live and
they didn't accept the situation, they were very vocal about it trying to speed
things up they said hurry up, mister scientist, or hurry up, mister politician,
let's fund this research because we don't have that much time left to live
and if you don't find a cure or some kind of intervention
to prolong our life — and quickly! — we are just going to die! And their activism really
helped turn the tide on HIV and turned it from a death sentence into a manageable
condition that people live for decades now and they've done it quickly:
by the 1990s already all these antiretroviral cocktails were helping people
live for much longer than initially a year and a half. So I think if we embrace that paradigm of the terminally ill people with trying to do
translation of research as fast as possible and try to convince scientists
and politicians in the urgency of finding at least something that can
delay aging or fix it outright, I think we have better odds of surviving and
helping our loved ones, our parents and grandparents to also survive long
enough to enjoy the real rejuvenation therapies. I hope I didn't ramble on for
too long, and hopefully some of what I had to say was useful for at
least some people. So that was my perspective… Thanks!

1 comment

  1. как всегда полностью тебя поддерживаю Юра 100%, поддерживаю то что люди думают не о важном это точно. Ещё люди не думают о растущей гарантированной угрозе. Это список факторов которые накапливаются на планете земля и за ее пределами. И если вовремя не открыть долголетие и бессмертие то мы все станем заложниками обстоятельств смерти всей нашей цивилизации. Список гарантированных угроз это :
    1 Мутация факторов аллергии и супербактерий.
    2 Этапное перераспределение активности флоры и снижение фотосинтеза. Как следствие полная смена фауны и микробиоты этой фауны.
    3 нано-компонетное загрязнение графен и другие карбониты и материалы композитволокна, всё чаще становятся причинами возникновения патологий в мире.
    И ещё список из 50 пунктов… И у людей просто нет выбора чтоб спастись нам нужны такие инструменты как продление жизни. И это угрозы ближайших 15 лет если что. .. долголетие позволяет накапливать эффективность научного и профессионального потенциала людей. Что уже само по себе увеличивает шанс на успех во всех направлениях жизнедеятельности человека и общества.

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