Asthma Medication & Principles of Therapy– Respiratory Pharmacology | Lecturio



welcome to pharmacology by luxury Oh my name is praveen Shukla and I will guide you through respiratory pharmacology when we talk about drugs used in asthma we have lots of choices we have the bronchodilators such as the beta agonists the methylxanthines and the muscarinic antagonists we also have a choice of a number of anti-inflammatory agents including release inhibitors slow anti-inflammatory drugs antibody based therapies and of course steroids and finally we have the new class of drugs called the leukotriene antagonists they can be lipo oxygen ACE inhibitors or they can be receptor inhibitors these drug classes represent the entire armamentarium in asthma and we're going to go over each of them in turn before we do though let's start off with principles of therapy behind asthma treatment an inflamed airway has thick Airways and the airway itself is narrow so when you take a look at a normal airway down here you can see that the walls are not thick and the walls are wide and open when you took a take a look at a constricted airway you can see that the walls are still the same thickness but the entire diameter of the airway has narrowed resulting in a narrower lumen when you take a look at an inflamed airway even though the walls have not constricted in the walls themselves are thicker so you end up with a narrower airway and finally in you know end-stage asthma you will have a constricted and inflamed airway which results in a very linear lumen and real illness from a clinical point of view so inflamed Airways the walls are thick Airways narrow a constricted airway the walls are closed in and the airway is narrow now treatment involves two types of therapy you can bronchodilator or you can give anti-inflammatories to reduce thickness or you can do both

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