Doctor On CAR T, A New Cancer Therapy That Helped One Mom In Her Cancer Battle | Megyn Kelly TODAY

>>> WERE BACK NOW WITH EMILY >>> WERE BACK NOW WITH EMILY
DUMLER AND HER HUSBAND, SCOTT. DUMLER AND HER HUSBAND, SCOTT. EMILY WAS JUST 32 YEARS OLD WHEN EMILY WAS JUST 32 YEARS OLD WHEN SHE WAS DIAGNOSED WITH
NON-HODGKINS LYMPHOMA. NON-HODGKINS LYMPHOMA.
SHE WAS THE THIRD LYMPHOMA SHE WAS THE THIRD LYMPHOMA PATIENT IN THE WORLD TO BE
TREATED WITH A CUTTING EDGE TREATED WITH A CUTTING EDGE
TECHNOLOGY CALLED CAR-T. TECHNOLOGY CALLED CAR-T.
SO THIS COMES INTO YOUR LIFE AS SO THIS COMES INTO YOUR LIFE AS
A THING. A THING. WHETHER IT CAN DO ANYTHING FOR A WHETHER IT CAN DO ANYTHING FOR A LYMPHOMA PATIENT, NO ONE HAS ANY LYMPHOMA PATIENT, NO ONE HAS ANY IDEA. IDEA. THERES NO CLINICAL TRIAL UNDER
WAY.ES NO CLINICAL TRIAL UNDER WAY. SO HOW DO YOU GET YOURSELF THIS
THERAPY?O YOU GET YOURSELF THIS THERAPY? >> SO WE CALLED — IT WASNT
AVAILABLE IN KANSAS CITY, WHERE AVAILABLE IN KANSAS CITY, WHERE
IM FROM. IM FROM. AND SO MY DOCTORS THERE HELPED
ME FIND A CLINICAL TRIAL.ELPED ME FIND A CLINICAL TRIAL.
THEY CALLED DOWN TO M.D. AROUND THEY CALLED DOWN TO M.D. AROUND
ANDERSON IN HOUSTON. ANDERSON IN HOUSTON. >> ONE OF THE BEST HOSPITALS IN >> ONE OF THE BEST HOSPITALS IN THE WORLD. THE WORLD. >> ITS AMAZING. >> ITS AMAZING. AND THEY SAID ACTUALLY, WE HAVE AND THEY SAID ACTUALLY, WE HAVE A TRIAL OPENING NEXT WEEK AND WE A TRIAL OPENING NEXT WEEK AND WE HAVE ONE SPOT LEFT. HAVE ONE SPOT LEFT. AND SO I SAID I WANT THAT SPOT. AND SO I SAID I WANT THAT SPOT. AND THEY SAID YOU HAVE TO — YOU AND THEY SAID YOU HAVE TO — YOU HAVE TO BE DOWN HERE AND YOU HAVE TO BE DOWN HERE AND YOU HAVE TO QUALIFY. HAVE TO QUALIFY. AND SO I FLEW OUT AS SOON AS I AND SO I FLEW OUT AS SOON AS I COULD AND I GOT THE SPOT. COULD AND I GOT THE SPOT. >> YOUR DOCTOR IS HERE, RIGHT, >> YOUR DOCTOR IS HERE, RIGHT, ALSO JOINING US IS DR. JOSEPH
McKIRK WHO CAN SPEAK TO THISH McKIRK WHO CAN SPEAK TO THIS
THERAPY. THERAPY. CAN YOU PUT IT IN LAYMANS
TERMS?U PUT IT IN LAYMANS TERMS? >> YES, THIS IS A REVOLUTION IN >> YES, THIS IS A REVOLUTION IN CANCER MEDICINE. CANCER MEDICINE. IT INVOLVES OUR KNOWLEDGE OF THE IT INVOLVES OUR KNOWLEDGE OF THE IMMUNE SYSTEM AND HOW IT DOES IMMUNE SYSTEM AND HOW IT DOES NOT WORK IN ALLOWING CANCERS TO
DEVELOP IN THE FIRST PLACE,S TO DEVELOP IN THE FIRST PLACE,
TAKING BLOOD FROM THE PATIENT TO TAKING BLOOD FROM THE PATIENT TO THE LABORATORY, ISOLATING THE
IMMUNE CELLS CALLED T-CELLS.E IMMUNE CELLS CALLED T-CELLS.
REENGINEERING THEM TO RECOGNIZE REENGINEERING THEM TO RECOGNIZE
THE CANCER, INFUSING THAT BACK THE CANCER, INFUSING THAT BACK
INTO PATIENT. INTO PATIENT.
THEY SWEEP AROUND THE BODY, THEY SWEEP AROUND THE BODY,
ATTACH TO THE CANCER CELLS, ATTACH TO THE CANCER CELLS,
PUNCH A HOLE IN THE CANCER CELLS PUNCH A HOLE IN THE CANCER CELLS
AND RELEASE LITTLE MOLECULES AND RELEASE LITTLE MOLECULES
THAT RACE INTO THE CELL AND TEAR THAT RACE INTO THE CELL AND TEAR
ITS DNA APART AND THE CANCER ITS DNA APART AND THE CANCER
CELL DIES. CELL DIES.
ITS REALLY ABSOLUTELY ITS REALLY ABSOLUTELY
REVOLUTIONARY. REVOLUTIONARY. >> IT MAKES YOUR WHITE BLOOD
CELLS?MAKES YOUR WHITE BLOOD CELLS? >> THATS CORRECT. >> THATS CORRECT. >> IT MAKES THEM LIKE SUPER >> IT MAKES THEM LIKE SUPER HEROES AND THEY PUT THEM BACK IN
YOU.ES AND THEY PUT THEM BACK IN YOU. BUT THE THING IS WHEN YOU GO BUT THE THING IS WHEN YOU GO THROUGH CAR-T THERAPY THERES THROUGH CAR-T THERAPY THERES SOMETHING THAT OVERCOMES THE
PATIENT CALLED THE STORM.THE PATIENT CALLED THE STORM.
SCOTT, TELL US WHAT DID THAT SCOTT, TELL US WHAT DID THAT
LOOK LIKE IN EMILY? LOOK LIKE IN EMILY?
>> SO WHEN YOU REINFUSE THESE >> SO WHEN YOU REINFUSE THESE
CELLS BACK INTO THE PATIENT, CELLS BACK INTO THE PATIENT,
ITS SOMEWHAT ABNORMAL BECAUSE ITS SOMEWHAT ABNORMAL BECAUSE
THERES TOO MANY OF THESE CELLS THERES TOO MANY OF THESE CELLS
NOW AND THERES THIS BIG RELEASE NOW AND THERES THIS BIG RELEASE
OF THESE CYTOKINS SO IT CALLS A OF THESE CYTOKINS SO IT CALLS A
NEURO NEURO NEUROTOXIS.
THE PATIENT PRIOR TO EMILY HAD THE PATIENT PRIOR TO EMILY HAD
SOME OF THIS HAPPEN. SOME OF THIS HAPPEN. WHAT IT LOOKS LIKE IS THAT IT WHAT IT LOOKS LIKE IS THAT IT BASICALLY — THE WAY I DESCRIBED BASICALLY — THE WAY I DESCRIBED IT TO EMILY WAS THAT SHE JUST
HAD THIS — SHE WAS AWAKE BUT HAD THIS — SHE WAS AWAKE BUT
HAD A COMPLETELY BLANK STARE. HAD A COMPLETELY BLANK STARE.
SHE DIDNT KNOW OUR CHILDRENS SHE DIDNT KNOW OUR CHILDRENS
NAMES. NAMES. THEY WOULD DO NEUROASSESSMENTS
WITH HER ALMOST HOURLY.SSMENTS WITH HER ALMOST HOURLY. AND THEY WOULD ASK HER A SIMPLE
QUESTION.WOULD ASK HER A SIMPLE QUESTION.
WHERE ARE YOU FROM? WHERE ARE YOU FROM?
AND SHE WOULD SPEND MAYBE 30 AND SHE WOULD SPEND MAYBE 30
SECONDS TRYING TO WRITE I LIVE SECONDS TRYING TO WRITE I LIVE
IN SHAWNEE, KANSAS, BUT SHE IN SHAWNEE, KANSAS, BUT SHE
WOULD JUST DRAW THIS LITTLE TINY WOULD JUST DRAW THIS LITTLE TINY
CIRCLE AND THEN SHE WOULD HAND CIRCLE AND THEN SHE WOULD HAND
IT IN. IT IN. >> AND YOU DIDNT KNOW WHETHER
SHE WAS EVER GOING TO COME OUT SHE WAS EVER GOING TO COME OUT
OF THAT. OF THAT. >> I DIDNT HAVE ANY IDEA IF SHE
WOULD EVER COME OUT OF THAT ORE WOULD EVER COME OUT OF THAT OR
NOT. NOT.
WE HAD HOPED. WE HAD HOPED.
THEY HAD TOLD US WE FEEL THIS IS THEY HAD TOLD US WE FEEL THIS IS
GOING TO PASS BUT UNTIL IT DOES, GOING TO PASS BUT UNTIL IT DOES,
YOU JUST THINK THAT THIS MAY BE YOU JUST THINK THAT THIS MAY BE
OUR NEW NORM, RIGHT? OUR NEW NORM, RIGHT?
>> SO YOU DONT KNOW WHETHER THE >> SO YOU DONT KNOW WHETHER THE
CAR-T IS WORKING. CAR-T IS WORKING.
>> RIGHT. >> RIGHT. >> YOU DONT KNOW WHETHER THE
NEUROTOXICITY WILL BE LASTING OR NEUROTOXICITY WILL BE LASTING OR
NEVER RECOVERABLE FROM, AND YET NEVER RECOVERABLE FROM, AND YET
THEY DID GET ANSWERS TO ALL OF THEY DID GET ANSWERS TO ALL OF
THAT AND, MAN, OH MAN, DID FAITH THAT AND, MAN, OH MAN, DID FAITH
PLAY A ROLE IN ALL OF THIS.

3 comments

  1. This is Part 2 of a TWO Part video interview. Part I is titled, "Doctor On CAR T, A New Cancer Therapy That Helped One Mom In Her Cancer Battle | Megyn Kelly TODAY" and is at this link; https://www.youtube.com/watch?v=FWbqLEDg1T0&t=1s

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