Dr. Rhonda Patrick Explains the Cause of Heart Disease

I started looking at well what are like the major causes of death like in the United States for example if you look at the major causes of death United States cardiovascular disease number one cancer is number two so most people that are dying when they die they die of cancer cardiovascular disease and then the second most common thing that I have is cancer and if you think about that and studies have actually shown for cardiovascular disease like eighty percent of that is preventable by diet so percent eighty percent so in the context of cardiovascular disease and this is where I started to really dive into this you know heart health a decade ago or so we were we were all told maybe it's two decades by now I don't know times flying we were all told that you know to have good heart health you need to decrease your saturated fat intake right it's all cholesterol clogs up your arteries and when you have cholesterol clogging up your arteries plaques form they rupture when they rupture then this causes a clot to form and then if the clot forms in an artery to your heart you have a heart attack if it forms in an artery to your brain you have a stroke and we were bled to believe this is all because of you know the fat we eat and we know now that it's much much more complicated than that and in fact that thought like did a lot more damage because then people started to eat something called trans fats which like did so much more damage than you know eating regular fat and recently the FDA thank God like banned all trans fats and so we have like very recently very recently yeah how long do they sell trans fats for I don't know but it's decade by decade my mom I remember my mom buying margarine I mean margarine is trans fats oh yeah yes that's illegal now it's ill they have three years to get it off the shelves can't believe it's not butter you're you I mean it's not butter eat butter it's it's bad it causes your cells to become really stiff which is what happens when you age because of damage so it's like aging in accelerated time and it causes you know heart disease all sorts of problems I mean so bad but um back to there cause the actual cause of it of this cardiovascular disease it actually I think comes down to gut health I know I talk a lot about micronutrients the importance of vitamins and minerals and that also plays a very important role in the way you age and you and I have talked a lot about this but I kind of wanted to touch a little bit on this topic because I think it's really important since you know I know my parents generation it's been really hard to de educate them and like help have them relearn everything they thought was bad and them understand well everything you thought was bad actually not bad and let me explain what actually is bad no because it I want them to be able to change their dietary habits and be healthy so I think most people that are educated in health know that it's not just about cholesterol they know well well it's LDL cholesterol and it's not just LDL cholesterol it's small dense particles right you've heard that mm-hmm most most people that are in the difference between HDL and LDL yeah so you actually need cholesterol LDL it's not actually cholesterol LDL is a lipoprotein that transports cholesterol it transports fatty acids and other things but it's easy to think it's easy to call LDL cholesterol because that's what people think of as that like calling the subway people know could it transport I mean well kind of but one of the major things it's transporting is cholesterol okay so I think it's easier actually to yeah if you just say LDL people are like what's that but if you say LDL cholesterol I think you're like okay well like oh yeah I've heard of that you know so I just I think it's better to talk about it like that so people can relate so the LDL cholesterol transports cholesterol so LDL cholesterol transports cholesterol to your cells to your cells and your liver to your cells in your you know kidney to your cells in your muscle and it does that because every cell in your body needs cholesterol it's part of the membrane of the cell which is essential for the way the cell functions anytime you damage your cell anytime you're making you're making a new cell guess what it needs cholesterol you go out you go to the gym you work really hard you got some damage you need cholesterol to repair that damage so LDL brings the cholesterol to your cells once it gets to your cell then something cuts it off like a little piece of the cholesterol gets cuts off cut off the LDL and then the LDL goes back to the liver and it's recycled so that's in a normal situation so what happens is an HDL does what HDL does is HDL brings the cholesterol from your cells or from your arteries if it's built up and it just rips it off and brings it back to the liver so it's like it's basically taking cholesterol away from yourselves away from you know your your arteries the things that are built up in your arteries and your veins so it's removing that and bringing it to the liver so HDL is really important if you have too much of the bad type of cholesterol which is the small dense and and what let me explain what small dense is because I'm sure most people have no clue what that means it's like I said when LDL cholesterol is going to your cell to repair damage a little piece of it gets cleaved off and it's like okay here's a little piece of cholesterol here you go and now the LDL that's left is smaller because it donated some of that cholesterol to your cell to repair so now it's smaller what happens is though if you have unhealthy gut and we could talk about what causes that but if you have an unhealthy gut most of the back so there's like over 100 trillion bacteria in your gut and they're there because they're metabolizing the food you eat making them into fatty acids and you know proteins amino acids things like that they're breaking this down number yeah 100 trillion they're also making vitamins and minerals nice more people more than there have been people in the world ever just on trillion yeah just two in one body one body well you also have the highest concentration of immune cells in your gut most people when I ask them where do you think you have the highest concentration immune cells they're like oh your thymus or your basket in your in your blood you know nope in your gut the highest concentration of immune cells are in your gut and the reason for that is because your gut is actually exposed to the external environment so every time you eat food from the environment your your gut sees it so if there's something pathogenic there you need to have that immune response to make sure it's not going to take you out right so there's a lot of immune cells in your gut well there separated by what's called the gut barrier and when that becomes compromised which we can talk about in a minute what happens is your immune cells start to kill bacteria in your gut and this releases something that's part of the bacterial membrane called endotoxin endotoxin then gets into your bloodstream and guess what it binds to LDL cholesterol and the reason why it binds to it is there's these docking sites on the cholesterol the LDL cholesterol that soak it up like a sponge so anytime you're inflamed you actually increase your LDL production so you actually make more LDL cholesterol and which is why it's important anytime you get a blood lipid panel done from a doctor do it more than once because if you add some stressful event the night before something crazy you're inflamed you were sick your LDL cholesterol is going to be through the roof and you know it's just not going to be an accurate picture it's a snapshot of what's going on in your life at that time so so should you get several over the course of a few days to get a baseline yes you should get several like you know if you had something stressful happening wait till you're chilled out and then to another test you know like give it some time a couple weeks and again is it all real stress or could it be like rollercoaster stress like if you went on a crazy rollercoaster does that change your LDL levels like that kind of like artificial stress if you're if it's stressed you out enough likely hour of Terror like yeah like if you really like we're terrified if you're terrified yeah it might actually that might cause enough inflammation to to do that so your your cholesterol the reason your body does that is because the endotoxin that's released it's very damaging and it can I mean endotoxin being released in the system when you have enough of it it can cause sepsis and death so your body has this response mechanism of soaking up that endotoxin the cholesterol so it doesn't damage your tissues it doesn't damage your organs the problem is that when that endotoxin binds that cholesterol that LDL cholesterol that we just talked about that was donating a piece of cholesterol to your cells so it's smaller it binds on the same docking sites that that LDL cholesterol uses to go back to the liver and go to your circulation so then what happens is you're screwed because now that LDL cholesterol that's smaller has all this endotoxin there it can't go back to the liver it's stuck in your circulation and guess what endotoxin is like a signal for your immune cells where it's like hey I'm a foreign invader come attack me so now it's stuck in your circulation your immune cells are seeing this signal of endotoxin it's stuck to cholesterol but it's not bacteria it's cholesterol so they come and they try to kill it but they can't kill it because it's not a live bacteria it's your cholesterol with its endotoxin bound to it they secrete all these pro-inflammatory cytokines which recruit more and then you get this beginning of a plaque or what it's called a foam cell which is a bunch of immune cells stuck to this LDL particle so it's now small dense because it's got all the stuff and it's stuck there in your circulation so really if we look at the big picture of things you know saturated fat which does increase LDL cholesterol isn't such a bad thing unless you are under chronic inflammation you know chronic inflammation at the level of the gut so what causes that well if you think about your gut and the bacterial cells that are there and the immune cells that are there and how they're being separated by this it's really it's called mucin so your gut cells secrete something called mucin and it looks like mucus I mean it looks like snot it's like viscous and gross anyone that's had like inflammatory bowel disease and they've had like beast-like problems and there they can excrete it to their feces it's like all slimy that's mucin that's your gut barrier like coming out and that's not good so the mucin that's secreted by your gut cells is very very important because it's separating your immune cells from your bacteria so that you don't your immune cells aren't going crazy causing this whole inflammatory cascade and releasing endotoxin but in order for your gut cells to make mucin they require energy and your gut likes energy in this in this form of something called short chain fatty acids which are basically generated from fermentable fibers like vegetables fruits shower coats sauerkraut mushrooms have it these fermentable fibers get fermented by what's called commensal bacteria in your gut which are the good type of bacteria typically because they make these short chain fatty-acids and when they make them lactate butyrate propionate acetate those are the short chain fatty acids that sixty to ninety percent of that goes right to the gut epithelial cells and it fuels them to make mucin so your gut cells love it when those short chain fatty acids come in because they're going to crank out more musin and they're going to make sure that got barriers strong they're going to make sure that it's not breaking down that your immune cells not coming in contact with bacteria when you're not feeding it the right thing so if you're eating a lot of refined carbohydrates refined sugars what happens is there's a bunch of other bacteria in your gut that don't eat short-chain or don't eat ferment these fibers they like to take the sugar in and they take the sugar in and they're over growing so they're basically talk.you pieing space in your gut that the commensal bacteria that usually are making the good stuff would occupy so it's like well if you have bad stuff here that's less room for the good stuff right the other thing that's happening is that there's actually and this was shown very recently to blew my mind there's actually insulin resistance going on in the low at the level of the gut so the more sugar you eat your gut cells begin to not respond so that sugar and so they're getting starved of energy because now they can't take the sugar up into the cell to make newson because they're not responding they're become they're not making insulin to be able to do that and so now your gut cells are starving when they're starving they start breaking down mucin and you start to have inflammation so really the key to good at good gut health is to not eat these refined carbohydrates these refined sugars and to try to eat more of the good fermentable types of fiber like vegetables and fruits i mean these are early barley whole oats also have it and also mushrooms mushrooms have a type of it called beta glucans that are really when you eat oats and you cover the oats and brown sugar what happens there yeah that's not a good thing so refined sugar yeah the refined sugars not good but the thing that's super up my oatmeal we're on to Patrick do you put brown sugar in your own love it so anyway you did dad


  1. Interesting talk, however it's hard to believe any preached understanding of nutrition and human health. Reason: past nutritional beliefs were so wildly incorrect, yet those who preached those beliefs and touted those studies believed in their truth just as much as we believe in the truth of our current understanding of nutrition. How do we know we're not wildly incorrect now? In 20 years will the stuff she's said in this video be laughed at as wildly inaccurate?

  2. Dr. Patrick's talks, papers, and all aspects of her work fascinate me. I have no formal education, but all of these subjects interest me. Her delivery makes this material much more accessible to me, and helps keep my interest– with the progressive style in which she presents this data.
    She follows a very logical approach to presenting these facts.

  3. 9:55 Im confused… so saturated fat is a good thing unless your under chronic inflammation… the most anti-inflammatory diet (which literally reverses heart disease) is plant based. This can only mean one thing.. the more dairy and meat you eat (the more sat fat you eat) the more inflamed you become. She then goes on to say everything good for the gut in terms of short chain fatty acids (everything plant based) then blames insulin resistance entirely on sugar. Dr Walter Kempner in the 1940's was destroying diabetes by giving his most seriously ill patients white rice, fruit, juice, and sugar (not a healthy diet at all) yet it proved that its not sugar that causes this.. I mean they were fed sugar lol.. Its the cholesterol and Sat fats from animal products. This is amateur hour. I like watching Joe Rogan cause he is always learning new things on his own accord and not doing the same thing most of us do day in out but get someone that knows what they are talking about. I'm not even a doctor yet i can tell she has no idea. Just read genuine non industry funded studies or get Dr Esselstyn on your show (he literally reversed heart disease)

  4. I waited to hear Dr. Rhonda tell me what good foods to eat, but she went on so long explaining how every single cell in the body acts, that I died before she got to the point.

  5. Nicola Tesla – learn about physics if you want to uncover the mysteries of the universe. The USA is hopelessly caught up in biochemistry when it's proven a dead end when run by big pharma. Why not just fix all this stuff with physics? There's no need to figure out the trillions of combinations of chemical Cascades when you can just use physics to fix all these issues! You guys are taking the long way home and the USA is being leapfrogged by Russia, Germany, Czech republic, China, India, etc because of the American obsession with drugs / chems.

  6. Nice try but you still have a long way to go. Heart disease is just a symptom of adrenal exhaustion and run down liver or lung or pancreas. It's too simplified to speak of everything as a heart problem. Idiot cultures like the two hundred year old American experiment with drugs and surgery only recognize heart problems because they can't detect earlier problems in other organs. The USA needs to stop this reductionist BS and start learning from ancient cultures like holistic natural traditions from China and India, for starters. Blaming everything on the heart is ridiculously childishly oversimplified. The body is geared to protect the heart at all costs, so if you only get to the illness by the time it shows up in the heart, you have done a piss poor job of learning how to take care of the body. Gut dysbiosis is a wild goose chase where you can just find a good herbalist to fix this stuff. Cholesterol is not the bad guy. Cholesterol is your body's best attempt to harmonize the imbalances caused by pancreas fatigue, liver fatigue, and poor diet.

  7. This bimbo is why I don't listen to md's when it comes to nutrition. These comments prove roe jogan followers are just as dumb.

  8. I pretty much agree with everything this lady is saying. I am adopted. I have always had an iron gut – a seldom upset stomach, I eat a varied diet. My heart is rockin. My dad, who raised me, always had gut problems. He would vomit. Always had heart burn. Always was a picky eater. His butter was margarine. His dinner was fried food. He always made fun of me for being bigger than him. He was one-hundred-forty pounds. He died of a heart failure at sixty-seven. Which, in the society I grew up in, is young. His family have all lived (minus a cancer death) to at least eighty. Your stomach is your gas tank. It determines how your machine runs.

  9. A non-ideological vegan diet with maybe a portion or two of fish a week (for the omega3), the occasional egg dish and a lot of plant sterols like avocado and nuts will lower your cholesterol. And there are plenty of non trans fat margarines on the market. Nuttelex for example and those cholesterol absorption reducing spreads… Stay away from processed sugars and white flour products and dairy (except for pro-biotic, sugar free yogurt), stick to low GI carbohydrates. It's not all that complicated. All these products are available on supermarket shelves. And delicious they can be too, with a wee bit of imagination! So useful that bit of info about stress and LDL cholesterol. thank you Dr. Rhonda.

  10. Take 1MD Complete Probiotics Platinum or PRO-45! I'm a consumer and not affiliated with either companies. I used these two because they're the best out there! Remember, you get what you pay for. That said you should look for the following and this is critical: Ingredients transparency; list of the Strains used (at least more than 10 different types of strains), must contain at least 40 Billions of live Probiotics cultures, and it must have Prebiotics, which is food for the Probiotics! Now, you know what to buy!

  11. I was right with her until she said gut cells can't produce insulin..lol..more like the cells become insulin resistant..sugar is the devil!

  12. You can literally hear Joe Rogan ripping a bong as she goes over the importance of cholesterol is to cell repair. 5:15

  13. The food industry lies to sell food that kills you…but the marijuana industry does the same thing right? Oh I forgot marijuana is the healthiest thing you can put in your body, usually via breathing smoke into your lungs. You believe that crap don’t you?

  14. Bottom line: Saturated fat alone does not usually lead to heart disease, but combining it with a lot of refined sugar does.
    Thank you, this can actually save lives.

Leave a Reply

(*) Required, Your email will not be published