Evaluation of pharmaceutical suspension (A type of liquid dosage form)

Evaluation of suspension The first parameter for the evaluation of suspension is organoleptic characteristics Appearance, color, odour, taste etc. Transfer the suspension in clean glass container and we check for the color uniformity, odour, presence of air bubble inside the container check for the sticking of the particles on the wall of the container Check the taste of the product If changes are observed, then we can say that the product is unstable during the shelf life. The second part is particle size analysis The particle size analysis can be determined by use of the photomicroscopy. We can check whether changes in particle size is observed or not? We can check for the crystal shape We can check for the changes in the flocculation state i.e. flocculated suspension may be converted to deflocculated state or overflocculated state. or coagulated state The third parameter is sedimentation rate, i.e. rate of the sedimentation This can be determined by plotting a graph with time on X axis and sedimentation height on Y axis You shake the suspension and determine the height of the sediment Initially when you shake the bottle at that time the sedimentation height is highest As time passes, the height decreases and come to the equilibrium state We can find that if sedimentation height is high, it indicates that suspension can be dispersed with small amount of agitation Fourth parameter is sedimentation volume ratio Higher the value of Vr, the suspension can be re-dispersed easily with small amount of agitation Ideally it should be near to 1 The next parameter is viscosity that can be determined by Brookfield viscometer The next parameter is density suspension is mixed uniformly and then we can determine the density of the suspension Next parameter is pH that can be determined at a particular temperature and after settling equilibrium Next parameter is content uniformity The suspension is shaken and we can get the unit dose samples from the upper side, middle and lower side So from these different side we can collect the samples and amount of active pharmaceutical ingredient present in that particular unit dose This test ensures that after shaking, each unit dose contains labeled amount of active pharmaceutical ingredient Next parameter is dissolution testing Dissolution test can be carried out by adding specific amount of suspension in a polyvinylidene fluoride membrane pouch and USP type I basket apparatus

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