First CAR-T patient at Penn State Cancer Institute

>> Let us pray. Oh, God who caused the minds of the faithful
to unite in a single purpose, grab your — >> My name is Tim Card. I’ve been married to my wife Tricia for
almost 20 years. We have seven kids. The oldest is 18; the youngest is five. We live here in Mount Joy. We’ve lived here for 11 years now. Come on. Bring it in. >> I’m not throwing it that far. >> Throw it to me. Throw it. Yes. Give me another. Hit me again. Yeah. It kind of felt surreal like it felt like
an out of body experience like this isn’t happening to me. This can’t be right. I am 40 years old. I’m in the best shape of my life, so there’s
no way I have cancer. This is silly. It’s something else. This is something else. Every rung you go down the ladder, your chances
of beating this get less and less. We’ve done R-CHOP. We’ve done two rounds of that salvage chemo. I’ve done a round of radiation. And it keeps coming back, and it keeps not
responding to the treatment very well. CAR-T came into play because the type I have
is called diffuse large B cell non-Hodgkin’s lymphoma, and that’s one of the specific types
of cancer that CAR-T fights. >> Forty percent of all non-Hodgkin’s lymphoma
are diffuse large B cell lymphoma. And that is one of the most common type and
the one that the — the type that is very aggressive and sometimes have difficulty treating. >> The CAR-T is taking Tim’s lymphocytes out
of him and that’s done through a process called apheresis. So he had to have a special catheter put into
his chest to allow us to get adequate blood flows for the machine to get the lymphocytes
out of him. Those cells are then shipped out to California
to the Kite Pharmaceutical Company manufacturing plant. They are infected with the viruses that hold
— that have certain sequences that we’re trying to convert Tim’s lymphocytes to and
that they then have to be grown up to sufficient quantity. That process takes about 17 days. >> All right. Thank you. I’ll see you next week. >> Yeah. I think I’m going to be doing it on Monday. >> Okay. >> He then came in on a Sunday and on Monday
at 1:00 we took those — a little frozen bag of cells, thawed those, and then infused that
over about 30 minutes time. >> Hand this to you, we’re gonna check your band here Is that a meal voucher? >> This is Timothy Card. Date of birth 4/19 >> This is definitely the hardest thing I’ve
ever done. Hands down. Hands down the hardest thing I’ve ever done. [ Music ] I think a lot of it was just because it was
condensed. It was in such a short timeframe like 17 days
from start to finish. By the time I got in to the time I got out
was 17 days. But it was a really bad 17 days. I felt like there was no rest from it. There was no relief. It was just [inaudible] coming for that whole
time. As I said, it was hard. It was very physically/emotionally very demanding. >> This is right where the problem was right
there. >> Okay. >> And this — I don’t see — you know, there
may always be residual abnormality and that technically is then [inaudible] remission. >> Okay. >> The spot that was there before that was
bright is gone but to my eye, this looks all very good. >> I really had a hard time believing it. We’ve been so primed for bad news for so long. Good news is kind of unexpected. We didn’t really know what to do with it. I believe it was November 16th. It was the first day I got on my bike. I said I’m going to get better now. I’m not just going to recover. I’m going to get better. I’m going to start working back to where I
was before I got sick. That’s really where I want to be. I want to be close to where I was at before
I got sick, and I had to start some place. >> We are very proud. And we are very happy that we are able to
bring in this new treatment strategy to this area. And we are very happy that we are actually
treating these patients. They are getting better. >> The nurses, the staff, everybody at Hershey
Medical was phenomenal and I just — from the moment I walked through the door, you
know from the greeters and the valet all the way to the docs, like everybody was just incredible. And I can’t thank them enough for saving my
life. [ Music ]

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