Making Biologic Medicines for Patients: The Principles of Biopharmaceutical Manufacturing

watched in awe as Lionel Messi scores yet another impossible
goal, or maybe you’ve been transported to
another time and place when reading a novel by Anne Rice. What you may not realize is that without
biologic medicines, like human growth hormone, that small boy
from Argentina could not have reached his full potential as one
of the world’s greatest soccer players. And without insulin,
Anne Rice’s diabetes may have kept her from writing
some of her bestselling stories. [MUSIC PLAYING] Biologic medicines
helped millions of people worldwide overcome debilitating
or even fatal diseases. Manufacturing is the key to making
sure they can get these therapeutics. In this course, making biologic
medicines for patients, our team will walk you
through the steps required to make these lifesaving drugs. STACY SPRINGS: [INAUDIBLE] more robust. Biologic medicines or
proteins used his drugs. In this course, you’ll
learn about the key building blocks that make a protein. And you’ll learn about
how variation and protein structure, whether by design or as a
result of the manufacturing process, determine the safety
and efficacy of a drug. J CHRISTOPHER LOVE:
For millennia, people have used the power of
living cells to produce the essential staples by fermentation. You’ll learn how
biotechnology allows you to engineer some of those same cells
to produce biologic medicines instead of food. We’ll also look at how we can
design and operate by our reactors to maximize the
production of these drugs. What are the parts here
that we’re looking at? PAUL BARONE: We’ll take
you through the steps necessary to isolate the drug
from the cellular machinery to ensure it’s safe and efficacious. SPEAKER 1: So these are depth filters. For clarification– You’ll learn about how the
entire process is linked and how choices made upstream, which
is which cell line you choose, impact the purification design. You’ll also learn about how these
drugs are regulated to ensure the best possible patient experience. SPEAKER 2: And as you look through
it, you’ll see lots of little layers. J CHRISTOPHER LOVE: Along the way, we’ll
visit real manufacturing facilities to see how theoretical principles
are applied in practice. ALISON MOORE: Industry has been– We’ll talk with the
pioneers in the fields such as Nobel Laureate and co-founder
of Biogen Idec Professor Phil Sharpe. PHILLIP SHARP: It became a
very widely used technology. J CHRISTOPHER LOVE: We invite
you to go on this journey with us to learn how to make biologic
medicines so that you too could play a part in improving the
lives of millions today and tomorrow.


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