Milestones – The Transplant and Regenerative Medicine Centre

SickKids has a world-class transplant
and regenerative medicine centre. We developed the largest living liver donor program in the Western world and we have one of the best intestine rehabilitation
programs, developing innovative therapies to repair and regenerate the small
intestine. In 1969 SickKids completed the first
paediatric disease donor kidney transplant in Canada and remain the country’s largest paediatric kidney transplant program. We encourage living
donation and participation in the living donor kidney paired exchange program to
improve transplant outcomes and increase the pool of available donors. In 1996 SickKids pioneered the first
infant ABO incompatible heart transplant. This led to a significant
decrease in infant waitlist mortality and has increased survival for infant
heart transplant recipients around the world. Here at SickKids
we did the world’s first ABO incompatible infant lung transplant.
Until 2018 we were the only centre in the world that performed these
life-saving procedures in this format and now this innovative work has allowed
us to save children’s lives that may not have had any other options. Since the
first liver transplant was performed at The Hospital for Sick Children in 1986 the
ability to offer and integrate live donor liver transplantation is
absolutely one of our greatest achievements. Today approximately 50% of
all transplanted livers utilized for SickKids patients are donated by live
donors. Intestinal failure patients are
extremely complex and traditionally there was no coordinated care. The Group
for Improvement of Intestinal Function and Treatment was formed in November of 2002. The program has demonstrated improvement in the number of septic
complications, TPN independence and a decrease in mortality from liver failure
of 22 percent to less than 1 percent. The success of our individual organ
transplant programs would not be possible without a highly integrated
interdisciplinary team made up of specialists in the fields of transplant
pharmacy, dietetics, occupational and physiotherapy, child life and music
therapy, and nursing. We believe that a broad-based
multifaceted approach to treatment and healing enables all patients to achieve
a higher level of health literacy, superb outcomes and excellent graft survival
across organ groups.

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