Polygenic Risk Score Series | Discover How PRSs Will Impact Clinical Care



in order for genetic risk scores to go from the lab to the clinic I think that we need to do a better job in terms of constructing these risk scores we have to validate them as well we're actively investigating how useful polygenic risk scores can be in the prediction of osteoporosis and fracture the single biggest known risk factor is bone mineral density and that's a very heritable trade early predictors of disease are obviously most useful if you can do something about it in the case of having a higher risk for high levels of cholesterol for example and you could followed it up with an actual cholesterol test or take take medication like statins in psychiatry we often have this and often have a scenario where a patient has non clear diagnosis or in effect we're psychiatrists and mental health workers are waiting for their diagnosis to become clear during this time the patients tend to be on unnecessary drug medications or there are on the wrong drug medications we're using polygenic risk scores to derive algorithms that will allow clinicians to better identify those patients who will go on and develop schizophrenia for example at an earlier date and thus treat them more effectively Ghana no blue moon so no soccer game no Tammy no cancer hinder a stoker come on over some riskier card if you were to sell it or not more he's on you you cannot target down another honey some venomous polygenic risk scores will have a role in clinical medicine and it will be partly in preventive medicine and ultimately perhaps in identifying which treatments an individual should be given as a priority you you

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