Webinar – Analysis of Incoming Materials in Pharmaceutical Warehouses

Good morning and good afternoon everyone, depending on where you’re joining us from and welcome to today’s webinar My name is Chris from business review, and I’ll be your host It’s our pleasure to have B&W Tek with us today He’ll be discussing Analysis of Incoming Materials in Pharmaceutical Warehouses Today’s guest speaker is Dr. Enrique Lozano I’d like to welcome you to our webinar platform, this webinar is browser based So if you disconnect for any reason, please just click on the link you received in my email to rejoin the session In order to ask questions, please find the questions widget Just type them into the box at the top left-hand corner of your screen and click on it We we allocate some time at the end of the session to address any questions or thoughts that you may have Please use the Help widget if you require any assitance and you can move, recycle, and maximize any of the windows But now, please allow me to welcome Dr. Enrique, over to you Thank you Chris, and good morning, or good afternoon, or good evening to all of you that are joining us is this webinar Presented by B&W Tek We are going to address the Analysis of Incoming Materials in Pharmaceutical Warehouses My name is Enrique Lozano, and I’m a doctor with a PhD in Chemistry I’ve been working B&W Tek for the last six years, a collaboration with them So, Raman spectroscopy and B&W Tek, they have been together in the market for quite a number of years, B&W Tek is a company that specializes in the production of handheld portable devices Particularly the Pharmaceutical market has been well addressed with this company Since the end of 2000 where the company started producing systems for the FDA in the United States Ever since, the company has specialized more and more into the analysis of incoming materials in the warehouses, as well as other stages of the pharmaceutical production But, particularly it’s the incoming materials that has been a niche market for this company Introducing a number of items for the analysis Before going any further, let’s focus on the technology that the pharmaceutical companies could be using today This webinar is going to address, particularly, two of the potential technologies available; Raman and LIBS And we’re going to explain very quickly how those technologies can be used or should be used in the warehouse for the incoming material The first one, the most popular one is going to be Raman spectroscopy Raman spectroscopy is a technique developed By C.V. Raman in 1932, and basically what it does You can see the molecules moving very nicely in the presentation It is pattern vibrational molds on the molecules When a molecule is vibrated by a monochromatic radiation, a laser We can obtain, after scattering of the light, the fingerprint signature of each molecule And that will be reflected in one spectrum that contains the fingerprint of the different functional groups of that molecule This technique allows the specific characterization and identification of the molecules that you may have in your incoming materials Particularly with most of your organic materials The other technology that we are going to present today is LIBS which is an abbreviation for Laser Induced Breakdown Spectroscopy In terms of technology, it’s quite similar, we’re going to have a laser Instead of having a continuous laser like in Raman, we’re going to have a pulsed laser And this laser is going to be very powerful We’re going to have a laser that is capable to heat the sample and create a plasma So this one is going to be a destructive technology Then, the plasma is cooled down and it’s going to have a capability to emit emission light of the elements present on the sample Then the sample, the light can be collected by a spectrometer And then we’re going to have the fingerprint of the elements of material that we have present on the sample The big difference between the two technologies is that the Raman is a technology that can see through the packaging material LIBS is a technique that requires sample preparation and is going to involve a little laser ablation of the surface, meaning it’s going to destroy, partially, the sample In this webinar, we’re going to review very quickly the benefits of handheld instrumentation, particularly Raman and LIBS in the warehouse analysis of incoming material And as well, we’re going to describe a different level of portability, we’re going to describe the benefits of portable Raman instruments in the warehouse The handheld instrumentation should be focused really what is considered handheld devices and unfortunately there is some misleading concepts in the market when people refer to handheld devices, sometimes they describe products that are more portable, and not handheld Handheld should be a product that can be operated and manipulated with one hand, ideally In some particular cases, with two hands You should be able to have full portability and accessibility of the products and the samples with your hands at the same time Without the materials that those materials can analyze This next slide, this graph, very briefly what is the clinical portion agent material that can be analyzed in a warehouse The great majority of the product, about 85% Those numbers are average from the very large number of customers That represents, particularly one company, it would represent a very large number of companies So, about 85% of materials like API, excipients, solvents Or some salts that are used in the warehouse, can potentially be used and analyzed with the handheld Raman using a laser, 785 nanometers So, of the samples that may be present in the warehouse May have high levels of florescence Florescence is a natural physical process that masks the Raman signature And cannot be seen in this Raman signature and that florescent And that can be resolved sometimes by changing the laser frequency so we can use a laser using 1064 nanometers, and that can potentially resolve the problem There is a certain amount of samples that are not suitable for Raman spectroscopy, for example

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