Whack-a-Mole Medicine: David Sinclair’s Book LIFESPAN (Part 2)

13 comments

  1. OK Doc, I get the concept but can anyone trained to treat the human body & all it's ailments be expected to diagnose & treat all conditions? That would mean being able to do all types of surgical procedures, i.e., open heart, intestinal, kidney, gall bladder, brain, spinal, orthopedic, and the list goes on…… Plus monitor & control many disease processes, both non-infectious & infectious, etc… So, what is the alternative that you would recommend? Perhaps I am not understanding your premise in detail? Thanks for your videos…………….

  2. I'd make the argument that if you can take care of diabetes you could manage parts of cancer too. You've said that before about tissue damage I have witnessed the tissue damage first hand. With alcoholism especially the repeated sugar dosing causes serious damage to tissue which in turn could lead to cancer. It's just easier to see with alcoholism then with twinkies.

  3. Brilliant, there are moments when I watch your videos and my brain has a minor happy explosion. On a related matter, Metformin and Sirtin1,…. a 2018 Spanish publication confirms the molecular role of Metformin in aging)

  4. NIH can't fund study for "aging"? Ok, so why don't we call it "age related diseases"? Makes me think of the Greek myth of Tithonus who was granted immortality but as a feeble old man. Aging per se is not the issue, but rather how we age. If as an 80 year old we could retain the youth and vitality of a 20 year old that would be something. Metformin btw is a intestinal antagonist. Those of us with IBS, IBD, Chron's are well advised to minimize Metformin if not skip it altogether.

  5. NIH can't fund study for "aging"? Ok, so why don't we call it "age related diseases"? Makes me think of the Greek myth of Tithonus who was granted immortality but as a feeble old man. Aging per se is not the issue, but rather how we age. If as an 80 year old we could retain the youth and vitality of a 20 year old that would be something. Metformin btw is a intestinal antagonist. Those of us with IBS, IBD, Chron's are well advised to minimize Metformin if not skip it altogether.

  6. Thank you so much for another insightful video. It is fair to say that it is coming to the forefront in medical science that if the hormone insulin can be kept in check then most of the other hormones will tend to follow suit. Therefore it has been said that insulin is the dominant hormone in the human body. I disagree, I am not sure if it is classified technically as a hormone, but I think dopamine is the dominant hormone. When you tell most humans something that they don't want to hear or something that depresses them they simply choose to not believe it. On the contrary when you tell them anything that makes them happy they have much more of a tendency to believe it. Eating carbs makes humans immediately feel good through the release of dopamine in the brain so they choose to believe it is the right thing to do. This creates the no win situation for medical professionals. Any human accomplishment starts in the mind. If i tell a friend they need to ditch the pizza, doughnuts, potatoes and rice they tell me where i can go; If a health care professional tells them the same thing they find another health care professional that will say, well… if you just don't eat a lot of it you will be o.k. All accomplishments start in the mind. I guess you can lead a human to water but you can't make him drink. lol Keep up the good work you are a blessing!

  7. I’m only on page 36 of Sinclair’s book and it’s too bad it’s not written for most of us lesser mortals who never studied organic or biochemistry. I’m pretty good at following complicated pathways but parts of this are challenging to keep up, especially without a good biochemical dictionary close by.

    Still trying to wrap my wits around SIRT1 to SIRT7, mTOR (mammalian target of rapamycin), etc. but will hang in there.

    Nice to see he addresses insulin and he does intermittent fasting. Can’t wait to see more on those. But WAS surprised to hear that he gets hungry when he does intermittent fasting. He must not be doing it correctly since the appetite hormones (leptin & ghrelin0 are suppressed when on low carb or keto. That’s why you now hear Keto being referred to as the “never hungry” diet. Hmm.

    But I’m going to hang in there to the end.

    Thanks for doing this book review Dr. Ford!

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